2020 Discovery Biologics Intern

  • Merck & Co.
  • Boston, MA, USA
  • Oct 07, 2019
Internship Aerospace engineering Astronomy Biology Computer Science Chemical engineering Engineering Health Science Life Science Mathematics Medical Sciences Chemistry Civil engineering Physics Psychology Social Science Teaching/Academics Technology Veterinary medicine

Description

The Future Talent Program features internships that lasts up to 12 weeks and will include one or more projects.  These opportunities in our Research Labs can provide you with great development and a chance to see if we are the right company for your long-term goals. 

Our company's Protein Sciences department located in Boston, MA within Discovery Biologics is seeking two highly motivated undergraduate students studying biological sciences for internship opportunities. 

The first position will be in the molecular interactions team. This opportunity will provide an in-depth, hands-on experience with in vitro assay development with a variety of techniques including Biacore, MST, Forte Bio Octet, and MSD ELISA. Responsibilities of this role include developing assays for characterization of recombinant proteins and biological reagents to support the preclinical development of biopharmaceutical programs across multiple therapeutic areas. 

The second position will be in the molecular biology and antibody display team. The successful candidate is expected to use molecular biology methods to evaluate and optimize different antibody display formats and their binding to corresponding antigens. Specific learning opportunities include evaluating various antibody display formats involving molecular biology, surface display, and antibody binding evaluation, microbial transformation and handling (bacteria, yeast) 

Internship, Molecular Biology and Antibody Display Team:

The first opening within the Molecular Biology and Antibody Display group in Boston is seeking a summer intern student to work on molecular biology and antibody display. The successful candidate is expected to use molecular biology methods to evaluate and optimize different antibody display formats and their binding to corresponding antigens. 

Responsibilities

  • Evaluate various antibody display formats involving molecular biology, surface display, and antibody binding evaluation
  • Microbial transformation and handling (bacteria, yeast) 

Required Education:

  • Candidates must be currently pursuing a bachelor’s degree in molecular biology, biochemistry, bioengineering or related disciplines 

Preferred Experience and Skills:

  • Candidates should have hands-on experience in molecular biology and recombinant DNA techniques
  • Candidates should have experience in antibody discovery using yeast or phage display techniques
  • Candidates should have familiarity with key bioinformatics and sequence analysis software
  • Candidates should have experience in flow cytometry (highly desired)
  • Candidates should have experience working in a highly collaborative, multi-functional team environment 

Internship, Molecular Interactions Team:

The second opening within in the Molecular Interactions group would allow for an in-depth experience with quality control techniques used for the preliminary evaluation of proteins as well as binding assay development using non-cell-based approaches.The intern will be introduced to the various instruments and assay approaches in the initial period and then shift to supporting the development of binding assays to interrogate interactions of interest of one or more Biologics programs. A comprehensive experience for this intern would include exposure to basic concepts of binding interactions (i.e. antibody: antigen, receptor: ligand, receptor: glycan), method design for different assay mediums (Biacore/Fortebio, Microscale Thermophoresis, MSD ELISA etc.), and provide extensive hands-on experience with method development and data analysis. In addition, to binding assay development, intern will also get experience in developing epitope binning technique using variety of approaches. 

Complimentary to the primary pharmacology experience, the intern would be exposed to other bio-physical analytical techniques for the reagent quality assessments which is critical to support sound assay development such as, SDS PAGE, SEC and nanodrop protein concentration measurement. Ultimately, this intern experience would provide valuable exposure and hands-on experience with fundamental assays and technologies that are highly marketable for their future career endeavors. 

Required Education:

  • Candidates must be currently pursuing a bachelor’s degree in life sciences or related disciplines 

Preferred Experience and Skills:

  • Candidates should have experience in protein biochemical analysis since as SDS-PAGE and ELISA
  • Candidates should have experience working in a highly collaborative, multi-functional team environment

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Experience level of the applicant we want

Undergraduate, College / Sixth form, High School