Research Assistant in Medicinal Chemistry

  • Imperial College London
  • London, UK
  • Feb 26, 2019
Job - Full time Aerospace engineering Astronomy Biology Computer Science Chemical engineering Engineering Health Science Life Science Mathematics Medical Sciences Chemistry Civil engineering Physics Psychology Social Science Teaching/Academics Technology Veterinary medicine

Description

We are seeking an outstanding medicinal chemist to undertake chemistry and drug design in an ongoing Cancer Research UK drug discovery project in the group of Professor Ed Tate. This position is available full time from June 2019, or as soon as possible thereafter, for 4 months in the first instance. Building on exciting new evidence from animal models and recent discovery of novel covalent fragment-based ligands (e.g. Angew Chemie Intl Ed...

Job listing information

  • Reference NAT00394

  • Date posted 25 February 2019

  • Closing date 28 March 2019

Job summary

We are seeking an outstanding medicinal chemist to undertake chemistry and drug design in an ongoing Cancer Research UK drug discovery project in the group of Professor Ed Tate. This position is available full time from June 2019, or as soon as possible thereafter, for 4 months in the first instance. 

Building on exciting new evidence from animal models and recent discovery of novel covalent fragment-based ligands (e.g. Angew Chemie Intl Ed 2018, 5257), you will drive hit optimisation and lead discovery against a small GTPase we have recently identified as an important target driving metastasis in a range of cancers. You will undertake medicinal chemistry in a team of postdoctoral researchers and graduate students, including chemical and structural biologists at Imperial, and cancer biologists in the group of Prof Jim Norman at the CRUK Beatson Institute.

Duties and responsibilities

Main duties and responsibilities include:

  • Drive hit optimisation and lead discovery against a small GTPase
  • To take initiative in the planning and execution of research, and in the development of collaborations with other groups at Imperial, and external collaborators.
  • To identify and develop suitable techniques for the collection and analysis of data

Essential requirements

Essential Criteria

  • Hold a research-based master’s degree in a relevant field (e.g. drug discovery, medicinal chemistry, chemical biology), or an equivalent level of professional qualifications and experience
  • Strong research track record commensurate with your level of experience
  • Capability and creativity in ligand design for small GTPases 
  • Experience in assaying covalent fragment kinetics on small GTPases
  • Experience with photouncaging chemistry on modified proteins
  • High level skills in organic synthesis
  • Ability to set and attain research objectives in a multidisciplinary team.

Further information

You will join the world-leading Department of Chemistry at Imperial College London, which recently moved to new state-of-the art research facilities in the Molecular Sciences Research Hub at the Imperial White City Campus. This has allowed significant expansion of our research activities, including in medicinal chemistry, cell and chemical biology, and brings together molecular sciences research across the College and external partners to tackle global grand challenges. 

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel.

For informal enquiries about the post, please contact Prof Ed Tate: e.tate@imperial.ac.uk 
http://www3.imperial.ac.uk/people/e.tate.

For technical queries, please contact: recruitment@imperial.ac.uk 

Should you have any queries about the application process please contact: Nayrin Noori by email: n.noori@imperial.ac.uk.

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. 
http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/ 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Experience level of the applicant we want

Some work experience, Graduate