Codiak BioSciences

Founded in 2015, Codiak is building a unique platform to employ exosomes as therapeutics. Exosomes are an ancient, highly evolved, and natural messenger system that cells use to communicate. Exosomes are lipid nanoparticles that have unique protein and carbohydrate molecules on their surface that allow them to traffic in the body and be taken up efficiently by cells. At Codiak, we can engineer specific messages into the exosome system, effectively hijacking their biology to define a new class of medicines.

Codiak can precisely control the signals either on the surface of or within the exosome, and deliver a precise signal(s) to promote a therapeutic effect. We can target drugs broadly throughout the body and optimize their therapeutic potential. Harnessing exosomes, Codiak is creating a new class of therapeutics that will push the frontier of biological research and accelerate the evolution of modern medicine.

Codiak BioSciences 500 Technology Square 9th Floor Cambridge, MA 02139
May 31, 2018
Job - Full time
We’re seeking an experienced Scientist to join our growing Biology and Translational Science team and help us to fully develop the therapeutic potential of exosomes. The successful candidate will lead efforts towards the discovery of exosome-based immunotherapies with the goal of delivering novel therapeutics to address significant unmet medical need in cancer immunotherapy as well as broader indications. Responsibilities will include leading projects towards IND enabling studies by defining the strategy for in vitro and in vivo prosecution of targets, establishing relevant molecular and cellular immunological assays, and coordinating in vivo studies both internally and at CROs. The successful candidate will be expected to lead from the bench by taking a leadership role to drive projects forward while also executing necessary experiments. We are on the cusp of developing a novel therapeutic platform and the successful candidate will have the opportunity to join us on this exciting journey! Responsibilities Design in vitro and in vivo studies to assess the therapeutic potential of exosome-based therapeutics; Develop and optimize immune cell-based assays to assess the potency and magnitude of our exosomal therapeutics as compared to small molecule inhibitors or antibodies; Coordinate efforts across multiple departments to develop lead therapeutic candidates Design and manage in vivo studies with CROs; Propose new targets and therapeutic modalities that take advantage of the differentiated attributes of our exosome platform; Support on-going projects and assist in the execution of in vitro and ex vivo experimentation; Maintain an in-depth knowledge of fundamentals of immunology, immuno-oncology, and tumor biology; Regularly communicate the project strategy and results across the company. Qualifications Education and Experience: Ph.D. degree in immunology, cell biology, oncology or a similar discipline with at least 2 years of industry experience. This can include post doc experience within industry. Skills and Abilities: Passionate about scientific discovery, self-motivated, and eager to learn new skills and contribute to the success of the organization; Exceptional communication skills and the ability to thrive in an interdependent and idea-rich environment; Experience leading or being the biology functional lead on a project in a pharmaceutical or biotech company; Extensive experience with general immunologic assays including immune cell activation, proliferation, cytokine release, reporter assays, etc.; Hands-on experience with flow cytometry and fluency with the concepts underlying fluorescence-activated cell sorting (FACS) and magnetic automated cell sorting (MACS); Expertise in the screening and pharmacological assessment of lead molecules using dose-responses and generating IC/EC 50s; Familiarity with in vivo models for immuno-oncology, autoimmunity, and/or infectious diseases; Ability to identify and troubleshoot critical issues associated with innate and adaptive immune responses; Exceptional organizational and critical thinking skills; Strong work ethic and attention to detail. Preferred qualifications: Experience leading a project for immuno-oncology; Experience performing primary immune cell assays using human blood cells, PBMCs, mouse splenocytes, and mouse bone-marrow; Expertise in cancer immunotherapy, tumor xenograft, and mouse syngeneic tumor models would be highly desirable; Excellent communication and interpersonal skills demonstrated in a team environment; Effective team building and teamwork skills, and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors; Detail-oriented with the ability to identify and implement creative solutions; Ability to prioritize and manage time efficiently, understanding of the research process, validation, and regulations that apply to clinical investigations and laboratory studies that support regulatory submissions is desirable.     Apply Today! Those interested in contributing to Codiak BioSciences’ development of the nascent and exciting field of exosome technology are invited to email their CV.